Active cyclin B1–Cdk1 first appears on centrosomes in prophase

By M. Jackman, C. Lindon, Erich A. Nigg, J. Pines. Nature Cell Biology, 2003

657 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6c2a9a452fd96acdb56e99dbc22a1ba18755d6d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. J. Ferrell
2. J. Pines
3. O. Gavet
4. Erich A. Nigg
5. T. Y. Tsai
6. Qiong Yang

In Molecular Biology

1. J. Ferrell
2. J. Pines
3. O. Gavet
4. Aaron Aslanian
5. Erich A. Nigg
6. H. Reinhardt
7. J. Lees
8. Jeffrey A. Ubersax

In Oncology

1. J. Ferrell
2. Aaron Aslanian
3. Erich A. Nigg
4. H. Reinhardt
5. J. Lees
6. Michael B. Yaffe

Citations in the corpus

• p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. (2007, background): “Cdc25B is believed to function by activating Cdk1/Cyclin B at the centrosome in late G 2 as an initiator of early mitotic events (Jackman et al., 2003), while Cdc25C functions to further amplify Cdk1/CyclinB activity within a nuclear autoamplification loop once mitosis has begun (Hoffmann et al.,…”
• Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. (2010, background): “This site is only phosphorylated when CyclinB1-Cdk1 is activated (Borgne et al., 1999; Jackman et al., 2003), indicating that it is not recognized by other Cyclin-Cdks in the cell.”
• Mechanisms of specificity in protein phosphorylation (2007, background): “Cyclin B1 is localized in the cytoplasm during interphase and moves to the nucleus just before nuclear-envelope breakdown, where it accumulates on the mitotic spindl”
• Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance (2010, background): “Accordingly, our data identified a pool of Gwl localized at the centrosome during G2 phase, the same subcellular and temporal localization where cyclin B-Cdc2 is first activated (20).”
• Polo-like kinases and the orchestration of cell division (2004, background): “Recent evidence indicates that the initial activation of the Cdk1–cyclin-B complex occurs at the centrosom”