Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

By A. Burgess, S. Vigneron, E. Brioudes, J. Labbé, T. Lorca, A. Castro. Proceedings of the National Academy of Sciences of the United States of America, 2010

714 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4da53507cb2b145805813928105c57f407c9d009

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1. R. McCloy
2. Samuel Rogers
3. C. E. Caldon
4. T. Lorca
5. A. Castro
6. A. Burgess

Citations in the corpus

• Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events (2014, methodology): “Partial knockdown induces multiple mitotic defects, including elongated spindles, chromosome congression and segregation errors, and cytokinesis failure.(16,47) These are distinct from the phenotypes observed here, with partial Cdk1 inhibition inducing premature cytokinesis and whole-chromosome sepa”