Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling
By Wei Wu, A. Glinka, H. Delius, Christof Niehrs. 2000
206 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6c1dae9300bb61db20d4e655aff3b26842893951
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In Molecular Biology
Citations in the corpus
- Secreted antagonists of the Wnt signalling pathway (2003, background): “…ectopic Xwnt-8 in Xenopusembryos (Glinka et al., 1998) and inhibits Wnt-induced stabilisation of β-catenin (Fedi et al., 1999) and β-catenin/Tcf-dependent transcription of both artificial and endogenous genes in mammalian and amphibian cells, respectively (Wu et al., 2000; Brott and Sokol, 2002).”
- Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease (2008, background): “Notably, the activation of the Fz receptors by a proposed ligand antagonist is not unique to SFRP1: Dickkopf2, which belongs to a different family of Wnt antagonists, can activate Wnt canonical signalling by cooperating with at least three different Fz proteins (Wu et al., 2000).”
- Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling (2002, methodology): “Luciferase reporter and BRET assays Luciferase Wnt reporter assays in 293T cells were done in 96-well plates at least in triplicate as describe”
- LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “…are antagonists for Wnt signaling (Krupnik et al., 1999; Brott and Sokol, 2002; Mao and Niehrs, 2003), whereas Dkk2 can, paradoxically, inhibit or activate (albeit weakly) β-catenin signaling, depending on the experimental assays employed (Wu et al., 2000; Brott and Sokol, 2002; Li et al., 2002).”
- Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. (2004, background): “2003), and evidence suggests that these proteins, like the Wise protein, can function as either agonists or antagonists, depending on their cellular context (Wu et al. 2000; Mao and Niehrs 2003).”
- Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “In contrast, in HEK 293 or NIH 3T3 cells Dkk2 will inhibit a Wnt-Fz signal but activate the pathway, when cotransfected with Lrp5 or -6 (Wu et al., 2000; Li et al., 2002; Mao and Niehrs, 2003).”