VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

By J. Warner-Schmidt, R. Duman. 2007

436 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Wei Deng
3. R. Duman
4. Hongjun Song
5. E. Nestler
6. Chunmei Zhao
7. H. Schmidt
8. V. Krishnan

In Developmental Neuroscience

1. Fred H. Gage
2. Wei Deng
3. Hongjun Song
4. R. Duman
5. Chunmei Zhao
6. E. Nestler
7. James Bradley Aimone
8. Guo-li Ming

In Molecular Biology

1. E. Nestler
2. R. Duman
3. Fred H. Gage
4. V. Krishnan
5. Hongjun Song
6. Chunmei Zhao
7. Wei Deng
8. T. Madsen

Citations in the corpus

• Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “AHN and angiogenesis are co-regulated (Boldrini et al., 2012; Heine et al., 2005; Thored et al., 2007; Warner-Schmidt and Duman, 2007).”
• Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, methodology): “In non-irradiated animals, VEGF infusions significantly increase the number of newborn neurons (Warner-Schmidt & Duman, 2007) in addition to other cell types.”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “We have recently reported that chronic antidepressant administration, including SSRI, SNRI, and ECS, increases the expression of VEGF mRNA and protein in the hippocampus (Newton et al, 2003; Warner-Schmidt and Duman, 2007).”
• The molecular neurobiology of depression (2008, positive): “), as well as vascular endothelial growth factor (VEGF) and VGF, which themselves have antidepressant and pro-neurogenic properties in rodent”
• Adult neurogenesis and the olfactory system. (2009, background): “Neurotrophic factors, particularly BDNF and VEGF, are important for the neurogenic mechanisms of antidepressants and environment (Rossi et al., 2006; Castren et al., 2007; Warner-Schmidt and Duman, 2007).”
• GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “…neurogenesis might be an etiological factor for depression (Thomas and Peterson, 2008) and that adult hippocampal neurogenesis might be an essential target for the behavior effects of distinct antidepressants (Santarelli et al., 2003; Warner-Schmidt and Duman, 2007; Sahay and Hen, 2008).”
• The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “…antagonist of the receptor for the neurotrophin vascular endothelial growth factor (VEGF), also blocked cell proliferation and survival of immature neurons, as well as the restoration of hedonic reactivity, in antidepressant-treated CMS animals (Warner-Schmidt and Duman, 2007; Greene et al., 2009).”
• Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure (2011, positive): “Novelty-Suppressed Feeding Test (NSFT)—The NSFT was performed as previously described (31).”
• Mechanisms and functional implications of adult neurogenesis. (2008, positive): “The expression of VEGF and insulin-like growth factor 1 (IGF1) are also coregulated with SGZ neurogenesis by antidepressants (Warner-Schmidt and Duman, 2006, 2007).”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “In contrast, expression of VEGF protein and mRNA in the adult hippocampus is increased after chronic administration of chemical antidepressants (Warner-Schmidt and Duman, 2007) or ECS (Newton et al., 2003; Altar et al., 2004).”