Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling.
By S. Eyerich, K. Eyerich, D. Pennino, T. Carbone, F. Nasorri, S. Pallotta, F. Cianfarani, T. Odorisio, C. Traidl‐Hoffmann, H. Behrendt and 3 more. Journal of Clinical Investigation, 2009
1,119 citations recorded by the source corpus.
Subfields: Dermatology, Immunology
View Paper: https://www.semanticscholar.org/paper/6b34e70ac45c946300615f974436e7c9d1166a17
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Citations in the corpus
- Progressive activation of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis (2012, background): “The more modest contribution of the TH17 axis in patients with AD might result from inhibition of this pathway by activated TH2 cytokines in both acute and chronic AD skin.(42) Our data expand the prevailing view of pathogenic pathways(16) and have important implications for the treatment of acute a”
- Psoriasis Pathogenesis and the Development of Novel, Targeted Immune Therapies (2017, positive): “IL-17 also acts synergistically with TNF to potentiate IL-17–induced transcription of several proinflammatory genes (eg, TNF, IL-1b, IL-6, and IL-8),47-50 which activate mDCs and promote the differentiation of T17 cells in the skin and draining lymph nodes.32,51 Epidermal hyperplasia, a hallmark of ”
- Th2 Cytokines and Atopic Dermatitis (2011, background): “Th22 cells were first identified in patients with psoriasis, but are also detected in patients with AD [71].”
- Immunology of Psoriasis (2014, background): “Activation of Th22 cells results in increased production of IL-22, which can induce keratinocyte hyperplasia (14).”
- Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “Although IL-22 has been associated with inflammatory disorders, it might also have anti-inflammatory effects.(96,97) For example, IL-22 inhibits IFN-g–induced secretion of the proinflammatory chemokines CCL5/RANTES and CXCL10/interferon-inducible protein 10 and antagonizes IFN-g in lung inflammation”
- Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis (2010, positive): “Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-α) was identified in the epidermis of individuals with psoriasis.(22) Th22 clones derived from patients with psoriasis were stable in culture and exhibited a profile clearly separate from those of Th1, Th2, and Th17”