Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

By Trista E North, W. Goessling, Carl R Walkley, C. Lengerke, K. Kopani, Allegra M. Lord, Gerhard J. Weber, T. Bowman, I. Jang, T. Grosser and 4 more. Nature, 2007

1,147 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/6b327c3acc6931b1e725918cfe6873e44fabf41a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Leonard I. Zon
2. N. Speck
3. E. Dzierzak
4. J. Dick
5. D. Stainier
6. Daniel G. Tenen

In Hematology

1. Leonard I. Zon
2. J. Dick
3. E. Laurenti
4. Daniel G. Tenen

In Immunology

1. Dingzhi Wang
2. J. Dick
3. E. Dzierzak
4. Stuart H. Orkin
5. R. Dubois
6. N. Speck

Citations in the corpus

• Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration (2009, positive): “FACS and confocal microscopy were conducted as described (North et al., 2007). qPCR (primers shown in Table S1) and western blot analysis were performed on pooled whole embryo lysates.”
• Hematopoiesis: a human perspective. (2012, background): “BM cells with PGE2 before transplant resulted in a 4-fold increase in the number of HSCs (North et al., 2007).”
• Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Treatment of embryos with prostaglandin E2 (PGE2) augments stem cell production (North et al., 2007), most likely through the EP4 receptor, a G-coupled receptor specifically expressed in the aorta region and activated by PGE2 (Villablanca et al.”
• Eicosanoids and cancer (2010, background): “and regulates growth and development of both embryonic haematopoietic stem cells and adult stem cells in several different organism”
• The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “Lastly, it is of interest to note that recent studies suggest a role for COX-2/PGE2 signalling in the maintenance of haematopoietic stem cell homeostasis [94] and in the suppression of embryonic stem cell apoptosis [95].”
• Hematopoietic stem cells derive directly from aortic endothelium during development (2010, positive): “In the zebrafish embryo, we 9 and others 10 previously demonstrated that expression of a cmyb:eGFP transgene marks nascent HSCs along the ventral aspect of the DA between 28– 48 hpf.”
• Of lineage and legacy: the development of mammalian hematopoietic stem cells (2008, background): “In addition, prostaglandin E 2 and interleukin 1, which are normally associated with the regulation of inflammatory molecules, also affect hematopoiesis in the zebrafish and mouse AG”