Recovery of learning and memory is associated with chromatin remodelling

By André Fischer, F. Sananbenesi, Xinyu Wang, Matthew M. Dobbin, Li-Huei Tsai. Nature, 2007

1,196 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/6b191aa424d64df103a8788b7905746b7092c53b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. F. Lubin
2. T. Roth
3. E. Verdin
4. John C. Newman
5. J. Sweatt
6. H. Pape
7. Denis Paré
8. Li-Huei Tsai

In Neurology

1. E. Verdin
2. John C. Newman
3. J. Sweatt
4. H. Pape
5. Denis Paré

In Physiology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. John C. Newman
5. E. Verdin
6. Nicholas A. Bishop
7. Li-Huei Tsai
8. Leslie M. Thompson

Citations in the corpus

• Autism and Increased Paternal Age Related Changes in Global Levels of Gene Expression Regulation (2011, neutral): “expression regulation [14,15,16,17,18,19].”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, methodology): “…learning-induced transcription and the use of small-molecule HDAC inhibitors has been shown to augment memory consolidation and to 74 Genes, Brain and Behavior (2014) 13: 69–86 parallel the beneficial effects of environmental enrichment on cognitive function mechanistically (Fischer et al. 2007).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “, 2013) or by mimicking the beneficial effects of environmental enrichment (Fischer et al., 2007).”
• Multiple roles of HDAC inhibition in neurodegenerative conditions (2009, background): “More recently, Tsai and colleagues studied the role of chromatin remodeling in learning and memory in CK-p25 (CDK5 activator) transgenic mice in which the expression of p25, a protein implicated in various neurodegenerative conditions, can be switched on and off conditionally [98].”
• Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “In a model showing temporally and spatially restricted induction of neuronal loss through induction of p25 expression, mice treated with HDAC inhibitors recovered learning and memory deficit”
• Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, positive): “The importance of this mechanism is indicated by the finding that chromatin modifications through increased histone-tail acetylation induce dendritic sprouting, increase the number of synapses, and reinstate hippocampal-dependent learning and access to long-term memories upon exposure to an enriched”
• β-Hydroxybutyrate (2017, positive): “HDAC inhibitors also improve cognition in the CK-p25 dementia mouse model (28).”