IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

By Eugene E. Varfolomeev, J. Blankenship, S. Wayson, A. Fedorova, N. Kayagaki, Parie Garg, K. Zobel, Jasmin N. Dynek, L. Elliott, H. Wallweber and 5 more. Cell, 2007

949 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/6afeec19c4b09576a57ca5168e18fbafeec4f9eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Véronique Baud
2. M. Karin
3. G. Gores
4. N. Perkins
5. S. Ghosh
6. M. Hayden
7. Bharat B. Aggarwal
8. Shao-Cong Sun

In Molecular Biology

1. Véronique Baud
2. Fenghe Du
3. M. Karin
4. Xiaodong Wang
5. G. Gores
6. Liping Zhao
7. Guido Kroemer
8. N. Perkins

In Oncology

1. Véronique Baud
2. M. Karin
3. G. Gores
4. N. Perkins
5. Bharat B. Aggarwal
6. S. Grivennikov

Citations in the corpus

• Is NF-κB a good target for cancer therapy? Hopes and pitfalls (2009, background): “Within this complex, cIAP1 and cIAP2 are directly responsible for the degradative K48-linked polyubiquitylation of NI”
• Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. (2009, background): “TNF-a and RIPK1 Since Smac mimetic induces apoptosis in certain tumor lines as a result of autocrine TNF-a (Petersen et al., 2007; Vince et al., 2007; Varfolomeev et al., 2007), we checked whether autocrine TNF-a is required for the observed necrosis in HT-29 cells.”
• Life and death by death receptors (2009, background): “In addition to blocking the NF- B transcriptional activity, TNF signaling can also be switched from prosurvival to pro-cell death in transformed cells by simultaneous use of a Smac mimetic, a small molecule designed to resemble the N terminus of Smac that interacts with and inhibits XIAP, cIAP-1, an”
• cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. (2008, background): “(2007), as these do activate the canonical NF-kB pathway (Gaither et al., 2007; Varfolomeev et al., 2007; Vince et al., 2007).”