New tools for studying microglia in the mouse and human CNS

By Mariko L. Bennett, F. C. Bennett, S. A. Liddelow, Bahareh Ajami, Jennifer L Zamanian, Nathaniel B. Fernhoff, Sara B. Mulinyawe, Christopher J. Bohlen, Aykezar Adil, Andrew Tucker and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2016

1,627 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/78c1a553f53320789de1f6d89a52b9b09775c3ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Neurology

Citations in the corpus

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “Fcrls, which was previously described to be microglia-specific (25, 26), was also detectable in all hCAM subsets.”
iPSC-derived human microglia-like cells to study neurological diseases (2017, neutral): “Differential whole transcriptome gene analysis reveal that the core microglia transcriptome signature was refractory to CX3CL1/CD200, but expression of select microglia-enriched genes, including catechol-O-methyltransferase COMT(Bennett et al., 2016), CD52, a cell surface receptor that binds Siglec-”
The microenvironmental landscape of brain tumors (2017, background): “For example, Tmem119 is enriched on microglia, but not BMDMs, in human Cancer Cell 31, March 13, 2017 327 brain tissue and mouse models of inflammation (Bennett et al., 2016).”
Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma (2017, positive): “…specific genes (TMEM119, P2RY12, GPR34, OLFML3, SLC2A5, SALL1, ADORA3 for microglia and CRIP1, S100A8, S100A9, ANXA1, CD14 for macrophages) (Bennett et al., 2016) We then classified each cell as macrophage or microglia based on the combined expression of those genes, and found that the…”
Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes (2018, methodology): “To identify these subpopulations at the protein level, we stained saline- and LPC-injected lesions with anti-Ccl4 and anti-Tmem119, a marker selective to resident microglia and not downregulated at the protein level following injury (Bennett et al., 2016).”