Human Leukocyte Antigen‐G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells

By Z. Selmani, A. Naji, I. Zidi, B. Favier, Emilie Gaiffe, L. Obert, C. Borg, P. Saas, P. Tiberghien, N. Rouas-Freiss and 2 more. Stem Cells, 2008

1,017 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Transplantation

View Paper: https://www.semanticscholar.org/paper/6a975c6e83429784af1859ea8f7ced4bcb728857

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Maria Ester Bernardo
2. W. Fibbe
3. Aline M. Betancourt
4. Ruth S. Waterman
5. Suzanne L. Tomchuck
6. Sarah L. Henkle
7. D. Prockop

In Immunology

1. W. Fibbe
2. Maria Ester Bernardo
3. Aline M. Betancourt
4. Vito Pistoia
5. Ruth S. Waterman
6. Suzanne L. Tomchuck
7. L. Moretta
8. Antonio Uccelli

Citations in the corpus

• Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, positive): “The emergence of Tregs can be supported by MSCs by indirect and direct mechanisms: indirectly via the production of CCL18 by MSC-induced M2 macrophages and directly via the production of TGF-b by MSCs (Melief et al., 2013a).”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “Splenocytes treated with MSC-CM produce large amounts of IL-10,(153) which is an essential cytokine to induce MSCs to secrete soluble isoform of HLA-G5 to suppress innate immunity.(154) MSCs usually perform their therapeutic function through balancing proinflammatory and anti-inflammatory responses,”
• Mesenchymal stem cells in health and disease (2008, result): “Similar to resting NK cells, pre-activated NK cells had decreased proliferation, IFNγ production and cytotoxicity after culture with MSCs in vitro”
• A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype (2010, background): “Additionally, hMSCs are known to recruit and support T-regs as part of their immunedampening effects [52,53].”
• Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC (2011, background): “The soluble HLA-G5 has been shown to suppress T cell proliferation, NK cell-mediated cytotoxicity and IFNg production and to induce expansion of regulatory T cells (Tregs) [117].”