Elevated striatal dopamine function linked to prodromal signs of schizophrenia.

By Oliver D. Howes, A. Montgomery, M. Asselin, Robin M. Murray, I. Valli, P. Tabraham, E. Bramon-Bosch, L. Valmaggia, Louise Johns, M. Broome and 2 more. Archives of General Psychiatry, 2009

757 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/6a93dbbb9034551ece198a19b34c031ec3ccc610

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. McCutcheon
2. Oliver D. Howes
3. Colin G. DeYoung
4. J. Stone
5. Anissa Abi-Dargham

In Clinical Psychology

1. Colin G. DeYoung
2. Jordan B. Peterson
3. Rachael G. Grazioplene
4. Oliver D. Howes
5. Paul J Silvia
6. Scott Barry Kaufman
7. J. Rushton
8. P. Irwing

In Psychiatry and Mental health

1. R. McCutcheon
2. Oliver D. Howes
3. J. Stone
4. Anissa Abi-Dargham
5. Colin G. DeYoung
6. Jordan B. Peterson

Citations in the corpus

• The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, neutral): “’’ Furthermore, there is some evidence that the 2 are connected in the prodrome as well as in schizophrenia: greater striatal dopaminergic elevation in ‘‘prodromal individuals’’ is directly associated with poorer neurocognitive function and altered activation in frontal cortical areas during the tas”
• Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism. (2012, neutral): “…(DA) system plays a role in altruism as well as in schizophrenia (Carlsson and Carlsson, 2006; Ebstein et al., 2010; Gefvert et al., 2003; Howes et al., 2009; Reuter et al., 2011; Rilling et al., 2004), and this same DA system also participates in creativity (Chermahini and Hommel,…”
• Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms (2019, background): “Studies investigating presynaptic dopamine function in individuals at clinical high risk (CHR) of psychosis also found the greatest abnormality to be in the associative striatum [65,69], and that conversion from CHR to psychosis is associated with a progressive increase in dopamine synthesis capacit”
• Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, background): “…indicators of schizophrenia has found that increased striatal dopamine synthesis capacity is associated with worse performance on cognitive tasks (Howes et al., 2009b), and that it is correlated with altered cortical function during cognitive tasks prior to the onset of schizophrenia as well…”
• From madness to genius: The Openness/Intellect trait domain as a paradoxical simplex (2012, background): “The positive schizotypal symptoms (including magical ideation, unusual perceptual experiences, and aberrant salience) that characterize the prodromal symptoms of schizophrenia are associated with elevated striatal dopamine function (Howes et al., 2009; Kapur, 2003).”