Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms
By R. McCutcheon, Anissa Abi-Dargham, Oliver D. Howes. Trends in Neurosciences, 2019
664 citations recorded by the source corpus.
The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic regions causes psychotic symptoms. Recently, however, advances in neuroimaging techniques have led to the unanticipated finding that dopaminergic dysfunction in schizophrenia is greatest within nigrostriatal pathways, implicating the dorsal striatum in the pathophysiology and calling into question the mesolimbic theory. At the same time our knowledge of striatal anatomy and function has progressed, suggesting new mechanisms via which striatal dysfunction may contribute to the symptoms of schizophrenia. This Review draws together these developments, to explore what they mean for our understanding of the pathophysiology, clinical manifestations, and treatment of the disorder.
Subfields: Cellular and Molecular Neuroscience, Neurology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/6d08c1f49714258aa3d62ed693bbc07b6c40a497
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Neurology
In Psychiatry and Mental health
Citations in the corpus
- Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders (2021, background): “Schizophrenia is characterized by the dysregulation of the dopamine system [59].”
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, background): “Dopamine occupies a central role in the pathophysiology of schizophrenia [144 – 146].”