Learning-Related Plasticity in PE1 and Other Mushroom Body-Extrinsic Neurons in the Honeybee Brain

By Ryuichi Okada, J. Rybak, Gisela Manz, Randolf Menzel. 2007

156 citations recorded by the source corpus.

Extracellular recording were performed from mushroom body-extrinsic neurons while the animal was exposed to differential conditioning to two odors, the forward-paired conditioned stimulus (CS+; the odor that will be or has been paired with sucrose reward) and the unpaired CS− (the odor that will be or has been specifically unpaired with sucrose reward). A single neuron, the pedunculus-extrinsic neuron number 1 (PE1), was identified on the basis of its firing pattern, and other neurons were grouped together as non-PE1 neurons. PE1 reduces its response to CS+ and does not change its response to CS−after learning. Most non-PE1 neurons do not change their responses during learning, but some decrease, and one neuron increases its response to CS+. PE1 receives inhibitory synaptic inputs, and neuroanatomical studies indicate closely attached GABA-immune reactive profiles originating at least partially from neurons of the protocerebral–calycal tract (PCT). Thus, either the associative reduction of odor responses originates within the PE1 via a long-term depression (LTD)-like mechanism, or PE1 receives stronger inhibition for the learned odor from the PCT neurons or from Kenyon cells. In any event, as the decreased firing of PE1 correlates with the increased probability of behavioral responses, our data suggest that the mushroom bodies exert general inhibition over sensory–motor connections, which relaxes selectively for learned stimuli.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Sensory Systems

Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Consistent with this mechanism, the PE1 MBONs in honeybees (Okada et al., 2007) as well as the V2 cluster MBONs in Drosophila (Sejourne et al., 2011) reduce their response to a learned odor and depression of KC-MBON synapses has been shown for octopamine modulation in the locust MB (Cassenaer and…”
Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila (2011, background): “It has been proposed that this reduced response could be due to inhibitory GABAergic inputs onto PE”
Are mushroom bodies cerebellum-like structures? (2011, background): “However, the Pe1 neuron is known to display long-lasting depression in response to CSþ presentation after associative conditioning (Mauelshagen, 1993; Okada et al., 2007).”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “, 1997), where learning-related changes have also been seen (Mauelshagen, 1993; Okada et al., 2007; Strube-Bloss et al., 2011).”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, background): “Learning-related plasticity has been reported at the b-lobe outputs in both bees (Okada et al., 2007) and locusts (Cassenaer and Laurent, 2012), although the importance of these synaptic connections in the behavior of these insects is not known.”