Structural basis for the inhibition of caspase-3 by XIAP.

By S. Riedl, M. Renatus, R. Schwarzenbacher, Qiao Zhou, Chaohong Sun, Stephen W. Fesik, R. Liddington, G. Salvesen. Cell, 2001

797 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a4a1912beee7455f89d6d59483371717f93ae0b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Riedl
2. Yigong Shi
3. G. Salvesen
4. C. Duckett

In Molecular Biology

1. G. Salvesen
2. Simone Fulda
3. D. Vučić
4. S. Riedl
5. X. Wang
6. F. Scott
7. Yigong Shi
8. C. Duckett

Citations in the corpus

• IAP proteins: blocking the road to death's door (2002, background): “So, this important inhibitory domain in XIAP binds with high affinity to a surface that is conserved between caspase-3 and caspase-7, but XIAP is not a pseudosubstrate and functions solely to mask the active site in the caspas”
• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006, background): “By contrast, the caspase-3/BIR2 complex not only showed the entire BIR2 domain, but also revealed that the caspase small-subunit amino terminus docks in the IBM-interacting groove (Riedl et al, 2001).”
• Molecular mechanisms of caspase regulation during apoptosis (2004, background): “The molecular mechanism of IAP-mediated inhibition of effector caspases is revealed by the crystal structures of caspase-3 (Ref”
• Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “Inhibition of caspase 3 and caspase 7 involves the interaction of the linker region between the BIR1 and BIR2 domains of XIAP with the substrate-binding site of the activated caspas”
• The expanding role of mitochondria in apoptosis. (2001, background): “The linker sequence immediately preceding the BIR2 domain is involved in XIAP-mediated binding and inhibition of caspase-3 and caspase-7 (Sun et al. 1999; Chai et al. 2001; Huang 2001; Riedl et al. 2001).”
• Cellular mechanisms controlling caspase activation and function. (2013, background): “XIAP can inhibit caspase-3 and caspase-7 by binding to the active site, and caspase-9 by preventing or reversing dimerization (Deveraux et al. 1997; Chai et al. 2001; Riedl et al. 2001; Srinivasula et al. 2001; Shiozaki et al. 2003).”