The neurobiology of glia in the context of water and ion homeostasis.

By M. Simard, Maiken Nedergaard. Neuroscience, 2004

646 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/6a17f3b29fb6c9ad75d161ba34c23adaa75c1a5b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. Maiken Nedergaard
3. M. Pekny
4. M. Pekna
5. H. Vinters
6. S. Goldman
7. N. Oberheim
8. N. Danbolt

In Neurology

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. Hans Lassmann
5. Maiken Nedergaard
6. C. Lucchinetti
7. H. Vinters
8. S. Goldman

In Social Psychology

1. M. Sofroniew
2. Diego Cosmelli
3. Evan Thompson
4. Hanne De Jaegher

Citations in the corpus

• Mitochondria and neuronal activity. (2007, background): “Astrocytes are also central for provision of precursors and other substrates to neurons, regulation of extracellular ion homeostasis, transport and metabolism of neurotransmitters, ammonia detoxification, and volume regulation (161, 188, 200).”
• Uniquely hominid features of adult human astrocytes (2009, background): “Human protoplasmic astrocytes have increased GFAP in their end feet End feet are specialized structures of protoplasmic astrocytes that contact the vasculature and contribute to the blood– brain barrier (Simard and Nedergaard, 2004).”
• Embodiment or envatment? Reflections on the bodily basis of consciousness (2010, background): “…involving organs outside the brain, including such factors critical to neuronal function as electrolyte balance (Hebert, Brown, and Harris 1997; Simard and Nedergaard 2004; Yano, Brown, and Chattopadhyay 2004) and water homeostasis (Amiry-Moghaddam and Ottersen 2003; Grubb, Raichle, and…”
• Astrocytes: biology and pathology (2009, background): “rich in the aquaporin 4 (AQP4) water channel and in transporters for the uptake of K [212, 220, 264].”
• Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. (2007, background): “Neurons and astrocytes of the area postrema are an important target for circulating signals regulating blood pressure, cerebral blood flow and osmolarity, including angiotensin II, arginine, vasopressin and atriopeptins (Simard and Nedergaard, 2004).”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “The membrane of astrocyte processes is often in aposition also with other cell types in the CNS, such as neurons, endothelial cells, or pericytes, and this forms the basis for extensive cell-cell communication and processes, such as recycling of neurotransmitters or nutrition of neurons (181, 200, 2”
• Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia (2013, background): “…CNS and display various important functions, such as support of synaptic transmission by control of extracellular homeostasis (Faissner et al., 2010; Fellner et al., 2011), maintenance of the blood–brain barrier (Simard and Nedergaard, 2004), and regulation of the blood flow (Koehler et al., 2009).”
• The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction (2010, background): “Specifically, it has been proposed that water transport through the endfeet is rate-limiting in the development as well as resolution phase of brain edema (AmiryMoghaddam and Ottersen, 2003; Papadopoulos and Verkman, 2007; Simard and Nedergaard, 2004).”