NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.

By A. Barria, R. Malinow. Neuron, 2005

734 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5e1fbbc0344b4b1963aa4270e118eade2fb117ee

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Citations in the corpus

Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “, and this interaction is crucial for the generation of both sustained kinase activity and LT”
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (2008, positive): “Treatment with tamoxifen to elevate NR2B-LBD disrupted the interaction between a-CaMKII and NR2B and led to deficits in LTP induction and spatial learning (Zhou et al., 2007), consistent with an earlier study (Barria and Malinow, 2005).”
AMPARs and synaptic plasticity: the last 25 years. (2013, positive): “Disrupting this binding impairs LTP (Barria and Malinow, 2005; Halt et al., 2012; Zhou et al., 2007).”
Mechanisms of CaMKII action in long-term potentiation (2012, background): “LTP is greatly reduced by the overexpression of mutant variants of NR2B (variants with mutations affecting residues near S1303; AS/QD) that block CaMKII binding to the NMDA”
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders (2007, background): “Consistent with this, overexpression of NR2A-containing NMDARs reduces the magnitude of LTP in area CA1 of the hippocampu”
Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term (2010, positive): “Other groups have found that LTP can be blocked or partially blocked by NR2B antagonists in cultured hippocampal slices (Barria and Malinow, 2005), acute hippocampal slices (Bartlett et al., 2007; de Marchena et al., 2008), or slices from cingulate cortex (Zhao et al., 2005).”
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, positive): “Given that the NR2A/NR2B ratio appears to be an important determinant of NMDA receptor signaling, even subtle effects on NR2A expression by miRNAs might influence synaptic plasticity (Barria and Malinow, 2005; Kim et al., 2005; Philpot et al., 2007).”
Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “The association between active CaMKII and GluN2B seems to be required for LTP, although the phosphorylation target has not been identified (Barria and Malinow, 2005).”
Regulation of NMDA Receptor Subunit Expression and Its Implications for LTD, LTP, and Metaplasticity (2008, background): “We speculate that these receptors show intermediate Ca2þ permeability to the NR1/ NR2A and NR1/NR2B di-heteromers, and these tri-heteromeric NMDARs may modestly associate with CaMKII through the binding to NR2B (Barria and Malinow, 2005).”
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, positive): “NMDAR subtypes are known to be differentially expressed during early postnatal neuronal development and have recently been proposed to differentially regulate the form and degree of synaptic plasticity (Barria and Malinow, 2005; Barth and Malenka, 2001; Kim et al., 2005; Liu et al., 2004; Tang et al”