Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.

By H. Meier-Ewert, P. Ridker, N. Rifai, M. Regan, N. J. Price, David F. Dinges, J. Mullington. Journal of the American College of Cardiology, 2004

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Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective (2014, background): “Certain aspects of sleep disturbance, as well as sex differences, differentially impact inflammation, with evidence that poor sleep efficiency may be salient in the association with higher levels of CRP (Okun & Coussons-Read 2007) and IL-6 (Friedman et al. 2005), especially in women with poor social”
Hypothalamic regulation of sleep and circadian rhythms (2005, background): “Individuals who lose even small amounts of sleep on a daily basis show progressive impairment of cognitive performance and elevation of C-reactive protein, which predicts cardiovascular ris”
Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. (2006, background): “Experimental sleep deprivation has been found to alter immune responses(11,12) and is reported to increase circulating levels of inflammatory markers such as IL-6, tumor necrosis factor (TNF) , and C-reactive protein,(13-15) with significant elevations after only 1 night of sleep loss.(15) The cellu”
Sleep duration and mortality: a systematic review and meta‐analysis (2009, background): “…the association between sleep duration and mortality could be chronic inflammation as clinical studies have reported elevated inflammatory markers, including high-sensitivity Creactive protein and interleukin-6, during sleep deprivation conditions (Meier-Ewert et al., 2004; Shearer et al., 2001).”