Nucleotide receptors: an emerging family of regulatory molecules in blood cells.

By F. Di Virgilio, P. Chiozzi, D. Ferrari, S. Falzoni, J. M. Sanz, Anna Morelli, M. Torboli, Giorgio Bolognesi, O. Baricordi. Blood, 2001

779 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/698b5cbc11fa19786b41c71ec38b40ce3915f3cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. G. Burnstock

In Physiology

1. W. Junger
2. F. Di Virgilio
3. G. Haskó
4. S. Gordon
5. A. Mantovani
6. G. Burnstock
7. B. Cronstein
8. Guo-Yuan Yang

In Psychiatry and Mental health

1. W. Junger
2. A. Mantovani
3. G. Haskó
4. G. Burnstock

Citations in the corpus

• Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1 (2006, background): “High expression of nucleotide receptors endows M2 cells with sensors for tissue damage (50, 51), and preliminary data suggest that these ligands modulate relevant functions in this cell type (data not shown).”
• Adenosine: an endogenous regulator of innate immunity. (2004, background): “It is well established that adenine nucleotides have powerful immunoregulatory effects, which are mediated by P2-purinoceptors [ 10 ].”
• Immune cell regulation by autocrine purinergic signalling (2011, background): “T cells express many members of the P2X, P2Y and P1 receptor families, as well as the ENTPD1 ectonucleotidas”
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1 (2006, background): “One of the most striking features of this nucleotide is its unmatched ability to promote massive release of mature IL- from LPS-primed mononuclear phagocytes and other cell types (9).”
• Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “…the roles of purines in inflammation, they have a broad range of functions carried out through purinergic receptors on immune cells, including killing intracellular pathogens by inducing apoptosis of host macrophages, chemoattraction, and cell adhesion (Burnstock , 2001d; Di Virgilio et al., 2001).”
• The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway (2002, background): “…for the different kinetics of secretion of the two cytokines: a rapid secretion for IL-1β, induced by ATP, promptly released after activation (Bodin and Burnstock, 1998; Di Virgilio et al., 2001); and a delayed release for HMGB1, triggered by LPC, generated later in the site of inflammation.”