Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

By David Robbe, M. Kopf, A. Rémaury, J. Bockaert, O. Manzoni. Proceedings of the National Academy of Sciences of the United States of America, 2002

631 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/6977bb4c8f6b2b45b38e30877d3a381c86e2e42b

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “At most synapses, mGluR 5 activation initiates 2-AG releas”
Distinct coincidence detectors govern the corticostriatal spike timing‐dependent plasticity (2010, background): “2005, 2008), striatum (Gerdeman et al. 2002; Robbe et al. 2002; Kreitzer & Malenka, 2005; Lafourcade et al. 2007; Narushima et al. 2007) or cerebellum (Maejima et al.”
Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. (2007, background): “Another NMDA receptor-independent form of LTD can be induced by high-frequency synaptic stimulation through the activation of group 2 metabotropic glutamate receptors (Robbe et al. 2002).”
Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. (2003, neutral): “glia (Gerdeman et al. 2002; Robbe et al., 2002), amygdala”
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. (2003, neutral): “effect on IPSCs amplitude or PPR (n ϭ 5). synapses in striatum and nucleus accumbens ( Gerdeman et al., 2002; Robbe et al., 2002 ).”
The Neuroscience of Drug Reward and Addiction. (2019, neutral): “Cannabinoids also act in the NAc where medium spiny neurons (MSNs) are modulated by CB1R expressing GABAergic interneurons, and by CB1R expressing glutamate terminals originating from amygdala, hippocampus, and prefrontal cortex (3, 79, 152). paminergic inﬂuences on reward processing has not been as”
Endocannabinoid signaling and synaptic function (2012, background): “In addition to their expression in the periphery, TRPV1 channels have been found in the CNS (Cristino et al., 2006, 2008; Mezey et al., 2000; Puente et al., 2011; Roberts et al., 2004; Tó th et al., 2005) (but see Cavanaugh et al., 2011), where they appear to regulate synaptic function.”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “In the nucleus accumbens (NAc), eCB-LTD also requires postsynaptic activation of group I mGluRs and is modulated by drugs of abuse (Fourgeaud et al, 2004; Mato et al, 2004; Robbe et al, 2002b).”
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “…of CB1 and CB2 receptor-deficient mouse strains (Ledent et al., 1999; Zimmer et al., 1999; Buckley et al., 2000; Marsicano et al., 2002b; Robbe et al., 2002) was similarly important, as the use of these animals in combination with receptor antagonists can reinforce the putative…”
Role of endogenous cannabinoids in synaptic signaling. (2003, background): “However, the possibility that the reduced cannabinoid sensitivity may reflect the very low expression level of CB1 receptors in glutamatergic neurons cannot be excluded, and recent experiments demonstrating that evoked EPCS are not modulated by cannabinoids in CB1 knock-out mice may also favor this ”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “It is known that LTP and LTD occur at excitatory synapses on medium spiny neurons, the major cell type in the NAc (Kombian & Malenka 1994, Thomas et al. 2000), including a novel form of endocannabinoid mediated LTD (eCB-LTD) (Robbe et al. 2002).”