Unique lipoprotein phenotype and genotype associated with exceptional longevity.

By Nir Barzilai, G. Atzmon, C. Schechter, E. Schaefer, A. Cupples, Richard B. Lipton, Suzanne Cheng, A. Shuldiner. Journal of the American Medical Association (JAMA), 2003

597 citations recorded by the source corpus.

Subfields: Aging, Endocrinology, Diabetes and Metabolism, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/68d03444a0cec142689cee01b3dcf043604f9e15

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. A. Hulbert
2. R. Pamplona
3. C. Kenyon
4. W. Buttemer
5. R. Buffenstein
6. D. Costantini
7. R. DePinho
8. Ergun Sahin

In Endocrinology, Diabetes and Metabolism

1. C. Kenyon
2. J. Chapman
3. A. Kontush
4. Massimo F. Piepoli

In Pediatrics, Perinatology and Child Health

1. Deborah Lawlor
2. Nicholas J. Timpson
3. C. Kenyon
4. George Davey Smith
5. Stephen Burgess
6. J. Bowden
7. S. Thompson
8. Gibran Hemani

Citations in the corpus

• The genetics of ageing (2010, background): “Drugs that target cholesterol-ester transport protein, whose inhibition is genetically linked to exceptional longevit”
• Life and death: metabolic rate, membrane composition, and life span of animals. (2007, background): “Centenarians show a reduced susceptibility to lipid peroxidation than other human subjects, yet have higher levels of DHA (295, 329), which is associated with a decreased incidence of metabolic syndrome and cardiovascular disease and superior insulin sensitivity (21).”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “One set of downregulated genes, the apoliporotein genes, is intriguing since alleles predicted to reduce the function of genes involved in fat transport in humans are genetically linked to extreme longevity (Barzilai et al., 2003; Geesaman et al., 2003).”
• Newly identified loci that influence lipid concentrations and risk of coronary artery disease (2008, background): “Additional studies will show whether these variants are also associated with longevit”
• Mechanisms Underlying the Costs of Egg Production (2005, background): “Recent studies in humans have suggested a link between lipoprotein phenotype and longevity ( Barzilai et al. 2003 ), and in bees (Apis mellifera), the high-density lipoprotein vitellogenin may play a role in regulatory control of aging (Amdam et al. 2004).”
• Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis (2006, background): “, 2004; Gotto and Brinton, 2004); in addition, high concentrations of HDL-C ( 60 mg/dl) are typically associated with longevity (Barzilai et al., 2003; Barter, 2004).”