Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

By B. Xia, Qing Sheng, K. Nakanishi, A. Ohashi, Jianmin Wu, N. Christ, Xinggang Liu, M. Jasin, F. Couch, D. Livingston. Molecules and Cells, 2006

899 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/68172b2762d3962dfc9162b54414cf4071bd9614

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Citations in the corpus

Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “3) (Xia et al. 2006; Oliver et al. 2009; Sy et al. 2009; Zhang et al. 2009a,b).”
PALB2 is an integral component of the BRCA complex required for homologous recombination repair (2009, background): “Because it has been reported that a significant portion of PALB2 associates with BRCA2 (14), and BRCA1 also interacts with BRCA2 (5), we asked whether BRCA1, PALB2, and BRCA2 coexist in a protein complex.”
BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “The interaction of PALB2 with BRCA2 was shown to be essential for loading RAD51 onto RPA-bound ssDN”
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, positive): “PALB2: a link between BRCA1 and BRCA2 PALB2 was first identified as a BRCA2-interacting protein by mass spectrometry of proteins that immunoprecipitate with BRCA2 (Ref”
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “285e287 TNBC accounts for approximately 20% of breast cancers and is more commonly diagnosed in women younger than 40 years, as well as in African-American women.288 Genetically, 20% of patients with TNBC harbor a breast cancer gene (BRCA) mutation, particularly in BRCA1.”
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins (2007, background): “Indeed, another FA gene ( FANCN ) was later identified using the same strateg”
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “For instance, in human cells, BRCA1 promotes the localization of BRCA2 to damage foci through the BRCA2-binding protein PALB2 (Xia et al. 2006; Sy et al. 2009; Zhang et al. 2009a,b).”
Homologous recombination and its regulation (2012, background): “In addition, PALB2 and its oligomerization promote the delivery and stabilization of RAD51 to the site of DNA damage (197,200).”
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination (2010, positive): “PALB2 has been identified as a partner of BRCA2 and shown to be an essential upstream regulator of BRCA2′s intranuclear localization and its homologous recombination functio”
How the fanconi anemia pathway guards the genome. (2009, background): “repair employs a recombination-mediated event to complete the repair (156, 158, 161).”
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. (2007, methodology): “HR Assay HR assay was performed as described (Nakanishi et al., 2005; Xia et al., 2006), except instead of transfecting cells with an I-SceIexpressing plasmid, we used an adenovirus AdNGUS24i (kindly provided by Frank Graham, McMaster University) expressing the I-SceI enzyme.”