PALB2 is an integral component of the BRCA complex required for homologous recombination repair

By Shirley M. H. Sy, M. Huen, Junjie Chen. Proceedings of the National Academy of Sciences of the United States of America, 2009

626 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5d8767152298ecb1d31fa67acb217a9a52af1c4f

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In Genetics

1. M. Jasin
2. Stephen P. Jackson
3. M. Moynahan

In Molecular Biology

1. Stephen P. Jackson
2. M. Jasin
3. M. Moynahan
4. S. Polo
5. J. R. Chapman
6. S. Boulton
7. Weiran Feng
8. Yu Zhang

Citations in the corpus

• Structure and function of WD40 domain proteins (2011, neutral): “formation of the PALB2-BRCA1-BRCA2 complex (Sy et al., 2009).”
• Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, positive): “Tumour-promoting missense mutations in BRCA1 and BRCA2 that abrogate PALB2 binding have been identifie”
• Playing the end game: DNA double-strand break repair pathway choice. (2012, background): “Role of Coiled-Coil and BRCT-Mediated Protein Interactions BRCA1 is physically associated with BRCA2, a key HR factor, via interactions with the Partner and localizer of BRCA2 protein (PALB2) (Sy et al., 2009; Zhang et al., 2009).”
• BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “A fourth BRCA1-containing complex mediated through the BRCA1 coiled-coil domain is composed of PALB2 and BRCA2 and is specifically involved in DSB repair by H”
• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “3) (Xia et al. 2006; Oliver et al. 2009; Sy et al. 2009; Zhang et al. 2009a,b).”
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “For instance, in human cells, BRCA1 promotes the localization of BRCA2 to damage foci through the BRCA2-binding protein PALB2 (Xia et al. 2006; Sy et al. 2009; Zhang et al. 2009a,b).”
• Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination (2010, positive): “Furthermore, multiple independent studies have established PALB2 as the central core of a BRCA1–PALB2–BRCA2 complex essential for homologous recombinatio”