Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex

By M. Wehr, Anthony M. Zador. Nature, 2003

1,446 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/67933f5d3ac3f2e2f7e87d1951a6bd5831da4481

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In Cognitive Neuroscience

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Citations in the corpus

GABAA inhibition controls response gain in visual cortex (2011, positive): “The selectivity of inhibition matches that of excitation also in somatosensory cortex (Okun and Lampl, 2008) and in auditory cortex (Wehr and Zador, 2003).”
Rapid homeostasis by disinhibition during whisker map plasticity (2014, methodology): “Whisker-evoked excitatory and inhibitory synaptic conductances were estimated from wPSCs at five holding potentials using standard methods (31, 54).”
Oscillatory integration windows in neurons (2016, background): “Thus, integration windows provide a mechanism for reading out information contained in the precise timing of spikes (Pouille and Scanziani, 2001; Wehr and Zador, 2003; Luna and Schoppa, 2008).”
Toward a new theory of motor synergies. (2007, background): “They have been described and/or postulated for sensory systems of different modalities (Lund et al., 2003; Schoppa & Urban, 2003; Wehr & Zador, 2003; Ozeki et al., 2004) as well as for brain circuits traditionally associated with the production of movement (Fukai, 1999).”
Noise in the nervous system (2008, background): “However, the rich set of dendritic mechanisms that allow individual synapses to interact suggests that this 'background' activity is unlikely to be composed only of nois”
Functional selectivity and specific connectivity of inhibitory neurons in primary visual cortex (2018, neutral): “ri, j = 1 (b−a+1) b ∑ t=a fi, j(t) (6)”
Rhythms of the brain (2006, background): “Single neurons can respond in a highly reliable manner both in vivo and in vitro (Mainen and Sejnowski, 1995; Kara et al., 2000; Buracas et al., 1998; Wehr and Zador, 2003; Fellous et al., 2004; Ikegaya et al., 2004).”
Efficient codes and balanced networks (2016, background): “In visual, somatosensory and auditory cortices, the sudden occurrence of a sensory stimulus causes a sharp increase in excitatory currents, followed a few milliseconds later by a sharp increase in inhibitory currents 14,31,33,34 .”
Receptive field formation by interacting excitatory and inhibitory synaptic plasticity (2016, background): “In particular, inhibitory synapses tend to have slower dynamics than excitatory synapses (Wehr & Zador, 2003).”
Sparse Representation of Sounds in the Unanesthetized Auditory Cortex (2008, methodology): “Cell-attached recordings were obtained using standard blind patch-clamp recording techniques; for details on this technique see also [17,72,73].”
Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations. (2009, background): “This difference in the relative timing of excitation and inhibition is proposed to shape stimulus selectivity and precisely timed spike output (Priebe and Ferster, 2008; Wehr and Zador, 2003; Wilent and Contreras, 2005).”
A disinhibitory microcircuit for associative fear learning in the auditory cortex (2011, background): “The balance of excitation and inhibition is critical to circuit function, and is maintained under most conditions including sensory stimulation, when thalamocortical input typically recruits feed-forward inhibition a few milliseconds after direct excitatio”
GABAergic interneurons in the neocortex: From cellular properties to circuits (2016, neutral): “, 2000) for PCs to summate afferent inputs that will bring them to fire and transduce sensory signals (Gabernet et al., 2005; Wehr and Zador, 2003; Wilent and Contreras, 2005).”