Cilia and Hedgehog responsiveness in the mouse.

By Danwei Huangfu, K. Anderson. Proceedings of the National Academy of Sciences of the United States of America, 2005

852 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6775126d44fe117a722b04efee79ad8eaf49cd88

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Citations in the corpus

The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “The genes disrupted in these mutants encode several components of the IFT machinery, including the IFTB complex components IFT172 and IFT88 , as well as DYNC2H1, which is a subunit of the IFT-dedicated retrograde moto”
The ciliopathies: an emerging class of human genetic disorders. (2006, background): “Interestingly, the wimple (wim) and flexo (fxo) phenotypes, which include open neural tube, brain defects, and limb abnormalities, are caused by mutations in the IFT proteins IFT172 and polaris/IFT88, respectively, demonstrating that intact IFT, as well as the molecular motor Kif3a (kinesin), are re”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “With regard to Hh signaling, previous studies (Corbit et al., 2005; Haycraft et al., 2005; Huangfu and Anderson, 2005; Liu et al., 2005; May et al., 2005) have found that numerous proteins associated with cilia function (intraflagellar transport proteins) play a role in transduction of Hh signaling,”
A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition (2011, background): “Shh specifies vertebrate digit number and identity by preventing cilium-dependent formation of Gli3 repressor (Gli3-R”
Flies without centrioles. (2006, background): “By contrast, many types of vertebrate cells have a primary cilium, which, in some cells at least, is required for the cell to respond to certain extracellular signals (Corbit et al., 2005; Huangfu and Anderson, 2005; Schneider et al., 2005).”
Gli proteins in development and disease. (2011, background): “Many signaling components of the Hh pathway are localized within the cilia either under resting conditions or during pathway activation (Corbit et al. 2005, Haycraft et al. 2005, Huangfu & Anderson 2005, Liu et al. 2005).”
The graded response to Sonic Hedgehog depends on cilia architecture. (2007, background): “IFT proteins are required for both activity of Gli activator forms and for the proteolytic processing that generates Gli3 repressor (Huangfu and Anderson, 2005; May et al., 2005; Liu et al., 2005; Haycraft et al., 2005); as a result, IFT mutants lack all responses to Hh ligands.”
Mechanical control of stem cell differentiation (2008, background): “Primary cilia are receiving increasing attention following the discovery that these structures play key roles in controlling the Hedgehog signaling pathway (Huangfu and Anderson, 2005; Corbit et al., 2005), one of the major determinants of embryonic patterning (Ingham and McMahon, 2001; Hirokawa et ”
Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function (2005, result): “In agreement with previously published results [19,20], there was a marked increase in the ratio of the full-length Gli3 to the processed form of Gli3R in Tg737 mutants (Figure 3C), although some Gli3R is clearly evident.”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “The function of this organelle in NSCs remains unknown, but as discussed below, recent work indicates that primary cilia are important sites for signal reception, particularly sonic hedgehog (Shh) (Huangfu & Anderson 2005, Singla & Reiter 2006).”
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, positive): “Notably, recent studies have shown that the Hedgehog, Wnt, PDGF, and other signaling cascades are coordinated at cilia (Cano et al., 2004; Huangfu and Anderson, 2005; Liu et al., 2005; Schneider et al., 2005; Simons et al., 2005; Tanaka et al., 2005).”
Hedgehog Signaling in Development and Cancer (2008, neutral): “…suggested that the scaffolding role of Cos2 in Drosophila could correspond to that of primary cilia in mammals since the production of Gli R is compromised in mice with defects in the formation and/or function of primary cilia (Haycraft et al., 2005; Huangfu and Anderson, 2005; Liu et al., 2005).”