Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
By Jodie L Babitt, F. Huang, Diedra M. Wrighting, Yin Xia, Y. Sidis, T. Samad, J. Campagna, R. Chung, A. Schneyer, Clifford J. Woolf and 2 more. Nature Genetics, 2006
1,063 citations recorded by the source corpus.
Subfields: Genetics, Hematology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/66c323dee993c5f0a6e392ababfce249c0ad371c
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In Genetics
In Hematology
In Molecular Biology
- T. Ganz
- F. Canonne-Hergaux
- Randall T. Peterson
- Delphine Meynard
- H. Coppin
- M. Roth
- Léon Kautz
- Valérie Darnaud
Citations in the corpus
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. (2008, background): “Co-receptors such as members of the repulsive guidance molecule (RGM) family (including RGMa, DRAGON (RGMb) and hemojuvelin (HJV, RGMc)) enhance the response to low levels of BMP ligands in the target tissues in which they are expresse”
- Systemic iron homeostasis. (2013, background): “-6 (10, 265, 267), and this could explain its ability to antagonize BMP signaling.”
- Lack of the bone morphogenetic protein BMP6 induces massive iron overload (2009, background): “Hepcidin expression is controlled by the BMP signaling pathwa”
- High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin (2007, background): “Recently, transforming growth factor-β (TGFB) superfamily members have been identified as regulators of hepcidin expressio”
- BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism (2009, positive): “We have previously shown that hemojuvelin is a co-receptor for bone morphogenetic proteins (BMPs) and that BMP signals regulate hepcidin expression and iron metabolis”