A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

By E. Tzima, Mohamed Irani-Tehrani, W. Kiosses, E. Dejana, David A. Schultz, B. Engelhardt, G. Cao, H. Delisser, M. Schwartz. Nature, 2005

1,728 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/6636651b525475d6c915ac94e119f2fcf1029c69

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Citations in the corpus

Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. (2007, background): “, the vascular endothelial growth factor receptor Flk-1) (8, 77), the integrins (especially v 3, but also 2 1, 5 1, and 6 1) (28, 45, 59), G proteins and G protein-coupled receptors (36, 38, 51, 71), Ca(2) channel (83), and intercellular junction proteins (52, 73).”
Cell mechanics: integrating cell responses to mechanical stimuli. (2007, background): “Cells in solid tissues, by virtue of their surrounding protein matrices, likely sense and respond to applied forces in ways that are very different, for example, from blood cells flowing past endothelium (52).”
Vascular Endothelial Cell Biology: An Update (2019, background): “Previous research has identified a mechano-sensory complex at cell-cell junctions, consisting of PECAM-1, VE-cadherin, and VEGFR-2, which is required for the activation of a number of shear-dependent signalling pathways, mediating both cell alignment and activation of many pro-atherosclerotic pathwa”
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner (2010, background): “Also, endothelial cells coordinately align with shear flow (Tzima et al., 2005).”
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “This is consistent with the causal link between PECAM-1 and NF-κB, which revealed the absence of NF-κB activation near bifurcations of PECAM-1 KO aortae (Tzima et al., 2005).”
The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. (2009, background): “Junctional proteins such as VE-cadherin may also serve as flow sensors and transfer intracellular stimuli which help the cell to react to changes in flow conditions (Tzima et al., 2005).”
Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014, background): “Putative mechanotransducers have been identified from cultured endothelial cells or in the mature vasculature, including ion channels (44, 45), the apical glycocalyx (46), cytoskeleton (47), primary cilia (48), and a protein complex comprising PECAM1, vascular endothelial cadherin, and vascular endo”
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “This proinflammatory phenotype is probably mediated by PECAM-1, because PECAM-1-knockout mice do not exhibit activation of NF- B and the downstream inflammatory genes in regions of disturbed flow (239, 581).”
Mechanotransduction in vascular physiology and atherogenesis (2009, background): “The concept that force is transmitted to lateral structures in the cell was further supported when a protein complex comprising PECAM1, VE-cadherin and the transmembrane Tyr kinase vascular endothelial growth factor receptor 2 (VEGFR2; also known as FLK1 or KDR ), was found to mediate multiple resp”