Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

By R. Machold, S. Hayashi, M. Rutlin, M. Muzumdar, S. Nery, J. Corbin, A. Gritli-Linde, T. Dellovade, J. A. Porter, L. Rubin and 3 more. Neuron, 2003

747 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/66315ebaf45db90349fee9870cfb1cd9feae0408

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Citations in the corpus

Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, methodology): “Our previous study (Machold et al., 2003) made use of a conditional null Smo allele (Smoc/c), in conjunction with a Nestin-Cre driver mouse line (NestinCre/ ).”
For the long run: maintaining germinal niches in the adult brain. (2004, neutral): “9, 439–447. type of Smon/c;Ncre mice (Machold et al., 2003).”
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma (2008, positive): “The Shh transcriptional target Gli1 is expressed in proliferating CGNPs (Wechsler-Reya and Scott, 1999), and we could induce MB formation in Gli1-creERT2: SmoM2 mice until P14, but not at later postnatal stages (Table 1).”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “; moreover, it is similar to the effect of a conditional mutation of Shh or of its receptor, smoothened ( Smo”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “…of neuroblasts in the absence of Smoothened, an essential effector of Shh, although expansion of Mash1 type C cells was not observed, suggesting that Shh signaling regulates both maintenance of type B cells and proliferation of type C cells (Machold et al., 2003; Balordi and Fishell, 2007a,b).”
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells (2008, background): “A similar reduction in the size of the dentate is observed in Nestin::Cre; Smo fl/− mice at P1”