Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

By J. Nilsson, J. Skog, A. Nordstrand, V. Baranov, L. Mincheva-Nilsson, X. Breakefield, Anders Widmark. British Journal of Cancer, 2009

737 citations recorded by the source corpus.

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.

Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/65e79dcd9498cedccdbeac7dc24d76c105fec9cf

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In Cancer Research

1. Suresh Mathivanan
2. Richard J. Simpson
3. H. Ji
4. Raghu Kalluri
5. A. Vlassov
6. T. Whiteside
7. C. Théry
8. Hina Kalra

In Molecular Biology

1. Suresh Mathivanan
2. Richard J. Simpson
3. H. Ji
4. A. Vlassov
5. Raghu Kalluri
6. Christoph Kahlert
7. T. Whiteside
8. C. Théry

In Pulmonary and Respiratory Medicine

1. Raghu Kalluri

Citations in the corpus

• Tumor-derived exosomes and their role in cancer progression (2016, background): “The known prostate cancer mRNA biomarkers PCA-3 and the chimeric fusion oncoprotein TMPRSS2-ERG were detected in urine exosomes [126].”
• Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “Based on their results, the authors suggested that urinary exosomes can be applied for diagnostics and surveillance of prostate cancer [63].”
• Exosomes Derived from Mesenchymal Stem Cells (2014, background): “Urinary exosomes contain mRNAs that are markers of renal ischemia/reperfusion injury [43] and prostate cancer [44].”
• Exosomes: extracellular organelles important in intercellular communication. (2010, background): “[95] Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva-Nilsson L, Breakefield XO, Widmark A.”
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, neutral): “cancer patients (74); the protein claudin-4 in blood EV in”
• Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. (2012, background): “resulting from a chromosomal rearrangement, the TMPRSS2:ERG fusion [62].”