Trk receptors: roles in neuronal signal transduction.

By E. Huang, L. Reichardt. Annual Review of Biochemistry, 2003

2,596 citations recorded by the source corpus.

Subfields: Cancer Research, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/65206d45d878a1f469661740949ec27f9325a3a3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. L. Minichiello
2. B. Lu
3. G. Lietzau
4. Janusz Morys
5. E. Czuba
6. Monika Waskow
7. A. Steliga
8. P. Kowiański

In Cellular and Molecular Neuroscience

1. B. Lu
2. Keri Martinowich
3. L. Minichiello
4. L. Reichardt
5. B. Hempstead
6. Undurti N. Das
7. Siresha Bathina
8. N. Woo

Citations in the corpus

• Model of autism: increased ratio of excitation/inhibition in key neural systems (2003, background): “One mechanism that could increase myelination would be higher than normal cortical and subcortical levels of BDNF, as it regulates myelin formation (Huang & Reichardt 2003), among its several roles described earlier.”
• BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “…66 within the BDNF gene in the pro-domain encoding region 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), phospholipase C-c (PLC-c), and guanosine triphosphate hydrolases (GTP-ases) of the Ras homolog (Rho) gene family (Gonzalez et al. 2016; Huang and Reichardt 2003; Minichiello 2009).”
• Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. (2007, background): “All neurotrophins (NT-3, NT-4/5, BDNF) bind to p75, while each NT is specific for a different Trk receptor subtype (A-, B-, and C) (Huang and Reichardt, 2003; Kalb, 2005).”
• A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling (2005, background): “Whereas expression of the neurotrophin receptors TrkA, TrkB, and TrkC marks afferents of distinct sensory modalities in DRG of wild-type embryos (Figure 6A–6C) [4,29], TauEWS-Pea3/þ Isl1Cre/þ embryos showed complete absence of expression of TrkA, TrkB, and TrkC in DRG neurons at E16.”
• The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain (2017, background): “BDNF belongs to the family of neurotrophic factors and is not only involved in the signaling pathways of the PFC and hippocampal dentate gyrus together with its receptor tropomyosin receptor kinase B (TrkB) but is also important in regulating neuroplasticity [32, 33].”
• Neuronal polarity: from extracellular signals to intracellular mechanisms (2007, background): “PI3K is known to mediate downstream signalling from tyrosine receptor kinases (Trks), which are receptors of neurotrophic factor”
• Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Binding of mature BDNF (mBDNF) to TrkB triggers tyrosine phosphorylation in its cytoplasmic domain, leading to activation of at least three signaling pathways: MEK–MAPK, phosphatidylinositol-3-kinase (PI3-K) and phospholipase C-g (PLC-g) (Kaplan and Miller, 2000; Chao, 2003; Huang and Reichardt, 200”
• Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB (2004, background): “Here, we report the identification of TrkB, a neurotrophic tyrosine kinase recepto”
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, background): “Mature BDNF interacts preferentially with TrkB to activate its intrinsic tyrosine kinase activity, which in turn triggers multiple intracellular signaling pathway”