Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

By Sirith Douma, Theo van Laar, J. Zevenhoven, R. Meuwissen, E. Garderen, D. Peeper. Nature, 2004

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How researchers see this paper

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Anti-apoptosis and cell survival: a review. (2011, neutral): “[412,413].”
Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “This antagonism can be achieved via the autocrine secretion of growth factors or the overexpression of receptor tyrosine kinases [13,96].”
Genetic determinants of cancer metastasis (2007, background): “However, the complexities and costs that are associated with carrying out such screens in mammals have prompted investigators to use surrogate in vitro assay”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “The survival of DTCs may also be related to their ability to withstand anoikis, for example through the expression of the tyrosine kinase receptor TrkB (Douma et al., 2004) or through non-canonical WNT signaling mediated by WNT2 (Yu et al., 2012).”
New signals from the invasive front (2006, background): “For example, an elegant expression-cloning approach recently identified TrkB, a neurotrophic RTK for brain-derived neurotrophic factor (BDNF), as a suppressor of cell death induced by the lack of cell-matrix adhesion (anoikis”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “Also of interest, the tyrosine kinase TrkB was identified as a suppressor of anoikis whose expression is required for metastatic progression in transformed intestinal epithelial cells (Douma et al., 2004).”