Review Cancer Susceptibility and the Functions of BRCA1 and BRCA2

By A. Venkitaraman. 2002

1,654 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/651e567ed3dc9ec50f5b92d2ebad6c0106623a92

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Citations in the corpus

A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase (2007, background): “Many subsequent studies have found that BRCA1 not only has an E3 ubiquitin ligase function but also has a transcriptional activation functio”
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers (2009, background): “Whereas multiple functions for BRCA1 have been described, such as in the DNA damage response, X-chromosome inactivation and transcriptional and cell cycle contro”
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings (2011, background): “Hence, the BRCA1 and BRCA2 proteins are tumour suppressors and are required for d Toxicology, Stockholm ation of European Bioche ity, which can lead to cancer (Venkitaraman, 2002).”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “Consequently, BRCA2 deficiency in normal cells results in the accumulation of procarcinogenic or lethal chromosomal aberrations (Venkitaraman 2002).”
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. (2006, background): “Multiple cellular roles have been attributed to the breast cancer susceptibility proteins BRCA1 and BRCA2, including a role in DNA repair (1, 2).”
ATM and related protein kinases: safeguarding genome integrity (2003, background): “It also activates the expression of certain damage-responsive genes and is involved in the S-phase and G2–M checkpoint”
The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007, background): “Mutations that affect the alternative splicing of tumor suppressors, such as BRCA1/2 , WT1 , APC , TP73 (p73) and TSC1/2 , and result in their inactivation, account for some types of inherited and sporadic susceptibility to cance”
Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes (2012, background): “BRCA1 is a DNA damage repair protein where loss-of-function mutations typically lead to early onset of breast cancer and ovarian cancer [45].”
Recent Progress in the Diagnosis and Treatment of Ovarian Cancer (2011, background): “such as platinum agents) through recombination with undamaged, homologous DNA strands.(13)”
The role of double-strand break repair — insights from human genetics (2006, background): “Heterozygous mutations in BRCA1 and BRCA2 are also seen in some hereditary breast-cancer familie”
Pancreatic cancer biology and genetics (2002, background): “BRCA2 is necessary for the maintenance of genomic stability by regulating the homologous-recombination-based DNA-repair processes; consequently, BRCA2 deficiency in normal cells results in the accumulation of lethal chromosomal aberration”
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex (2002, background): “The interaction between BRCA2 and RAD51 is critical for the biological functions of both molecule”