Origins and functions of B-1 cells with notes on the role of CD5.

By R. Berland, H. Wortis. Annual Review of Immunology, 2002

834 citations recorded by the source corpus.

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In Immunology

Citations in the corpus

Antibody Polyreactivity in Health and Disease: Statu Variabilis (2013, background): “Ig genes of these cells usually lack somatic mutations (12, 14).”
B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. (2005, background): “B-1 lymphocytes represent a unique B cell population distinguished from conventional B (B-2) cells by their phenotype, anatomical localization, self-renewing capacity, and production of natural antibodies (Berland and Wortis, 2002; Hardy and Hayakawa, 2001).”
Recognition of microorganisms and activation of the immune response (2007, background): “The innate-like B cells known as B1 cells reside in the peritoneal and pleural cavities and produce mainly antibodies of the IgM class with specificities skewed towards some common bacterial polysaccharides and some self antigen”
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 (2003, background): “Finally, mVα19-Jα33 transcripts were amplified equally well from the lamina propria and MLN of xid and control mice (data not shown), indicating that B1 B cells, absent in xid mic”
Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70− (2011, background): “In contrast to conventional B2 cells, murine B1 cells derive from CD19+B220 progenitors, appear early in development, and preferentially locate to coelomic cavities (Herzenberg, 2000; Berland and Wortis, 2002; Rothstein, 2002; Dorshkind and Montecino-Rodriguez, 2007).”
The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, methodology): “For an in-depth discussion of the experimental details underlying each model the reader is referred to previously published review”