B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.

By K. Haas, J. Poe, D. Steeber, T. Tedder. Immunity, 2005

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Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70− (2011, background): “Natural Ig is vitally important in the early defense against bacterial and viral infections (Briles et al., 1981; Boes et al., 1998; Ochsenbein et al., 1999; Baumgarth et al., 2000; Haas et al., 2005), and may play a role in a wide variety of diseases through recognition of”
Causes, consequences, and reversal of immune system aging. (2013, positive): “Although present at a low frequency (61), B1 B cells play a critical role in the response to S. pneumoniae in mice by the secretion of anti-carbohydrate antibodies (62).”
Structure-function of the immune system in the spleen (2019, background): “The difference in function of their produced antibodies inspired the “division of labor hypothesis” to describe the observed phenotypic differences between B-1a and B-1b cells (76).”