Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

By E. Treiner, Livine Duban, S. Bahram, M. Radosavljevic, V. Wanner, F. Tilloy, P. Affaticati, S. Gilfillan, O. Lantz. Nature, 2003

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Subfields: Immunology

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Homeostatic immunity and the microbiota (2017, neutral): “The development of MAIT cells is highly dependent on the microbiota as these cells are absent in germ free mice (Treiner et al., 2003).”
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells (2010, background): “While MAIT cells have been reported in the gut lamina propria, they have also been described in the lung [19].”
Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “Last, ILCs isolated from human tonsils were found to produce IL-5 and IL-13, as well as IL-22, in response to ligands that bind the pattern recognition receptor Toll-like receptor 2 (TLR2) (68), indicating that ILCs may also react to microbial compounds.”
Development and selection of γδ T cells (2007, background): “Treiner E, et al. Selection of evolutionarily conserved mucosal-associated invariant T ecells by MR1.”
Antimicrobial activity of mucosal-associated invariant T cells (2010, background): “They are selected on the highly phylogenetically conserved major histocompatibility complex (MHC) class I–related molecule MR1 (α1 and α2 domains 90% homologous between mouse and human, compared with 60–70% for other MHC class I molecules”