Cyclooxygenase 2: a molecular target for cancer prevention and treatment.

By K. Subbaramaiah, A. Dannenberg. TIPS - Trends in Pharmacological Sciences, 2003

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Copper complexes as anticancer agents. (2009, background): “Piroxicam and meloxicam exhibited anticancer properties in various cancer cell lines and in animal models [274-278].”
Chronic inflammation and oxidative stress in human carcinogenesis (2007, background): “For example, the use of COX-2 inhibitors, like celecoxib, are now being tested as antitumor agents in clinical trials.(103) In fact, this drug reduces the number of colorectal polyps in patients with familial adenomatous polyposis.”
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals (2010, background): “Reports have demonstrated increased amounts of COX-2 in both premalignant and malignant tissues [120,121].”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “Therefore, it represents an important target for pharmaceutical interventio”
Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “COX-2 inhibitors will be particularly useful in the treatment of advanced breast cancers through inhibition not only of HER-2/ neu activity but also of aromatase activity [175].”
Targets of curcumin (2011, background): “COX-2, the inducible form of COX, can be selectively induced by mitogenic and inflammatory stimuli, which results in enhanced synthesis of prostaglandins in inflamed and neoplastic tissues [163,164].”