Requirement for p38α in Erythropoietin Expression

By K. Tamura, T. Sudo, U. Senftleben, A. Dadak, Richard J. Johnson, M. Karin. 2000

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Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. (2010, background): “This is demonstrated by gene knockout experiments in which deletion of the p38 gene leads to embryonic lethality due to placental and erythroid differentiation defects (286, 397), but mice carrying deletion of any of the other three isoforms are phenotypically normal (139).”
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. (2001, background): “While cytokines such as stress activated kinases p38 MAPK and JNK (Davis, IL-1 , IL-1 , and TNF can mediate cachectic states, 2000; Tamura et al., 2000; Chang and Karin 2001).”
Mitogen-activated protein kinases in apoptosis regulation (2004, background): “Moreover, one of the groups also suggested that p38a-MAPK plays a critical role, linking developmental and stress-induced erythropoiesis through regulation of Epo mRNA stabilization (Tamura et al., 2000).”