Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia.

By D. Volk, M. Austin, J. Pierri, Allan R. Sampson, D. Lewis. Archives of General Psychiatry, 2000

664 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Plant Science

View Paper: https://www.semanticscholar.org/paper/060a2def90186ed1406161c6e39ac2f783824b82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

In Cellular and Molecular Neuroscience

In Plant Science

Citations in the corpus

Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. (2000, background): “When RELN is down-regulated (as in the brain of schizophrenic patients and patients with bipolar disorder and psychosis), the DAB1-dependent regulation of protein synthesis declines perhaps leading to the downregulation of GAD67 gene expression found in basket or chandelier cells.(8) This hypothesis”
Gamma-Aminobutyric Acid Concentration is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression (2010, positive): “Monkey and humans studies have shown similar patterns of GAD67 deficits in subjects with and without exposure to antipsychotics (Volk et al., 2000; Hashimoto et al., 2008b).”
Abnormal neural oscillations and synchrony in schizophrenia (2010, background): “One widely replicated finding is a reduction in the mRNA of GAD67 (also known as glutamate decarboxylase 1), an enzyme that synthesizes GABA, in several cortical areas in patients with schizophreni”
The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “…research groups have found decreased expression of the mRNA for the 67 kilodalton isoform of glutamic acid decarboxylase (GAD 67 ), the synthesizing enzyme for GABA, in the dorsal prefrontal cortex (Akbarian et al. 1995; Guidotti et al. 2000; Volk et al. 2000) of subjects with schizophrenia.”
GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder (2001, background): “In the prefrontal cortex of schizophrenics, a reduction in the number of cells expressing GAD67 mRNA has been reported by two different groups (Akbarian et al. 1995; Volk et al. 2000).”
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia (2003, methodology): “…to the consistent findings across research groups of a deficit in GAD 67 expression in the PFC (Akbarian et al., 1995; Guidotti et al., 2000; Volk et al., 2000; Knable et al., 2002), Heckers et al. (2002) reported no significant alteration in the density of GAD 67 mRNA-positive cells or in…”
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “BDNF is known to be required for proper development and survival of dopaminergic, GABAergic, cholinergic, and serotonergic neurons (Pillai, 2008).”