Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

By T. Hashimoto, D. Volk, S. Eggan, K. Mirnics, J. Pierri, Zhuoxin Sun, Allan R. Sampson, D. Lewis. Journal of Neuroscience, 2003

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The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, positive): “Several recent reports implicate various gene families as being involved in pathology of schizophrenia using DNA microarray technology, ie, genes involved in signal transduction, cell growth and migration,(91) myelination,(89,99) regulation of presynaptic membrane function,(92,93) and c-aminobutyric”
Gamma-Aminobutyric Acid Concentration is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression (2010, positive): “In schizophrenia, postmortem studies have documented an 50% reduction in the number of PV neurons with detectable levels of GAD67 mRNA in the dorsolateral prefrontal cortex, in which PV neurons constitute 25% of all GABAergic neurons (Hashimoto et al., 2003).”