GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder

By F. Benes, S. Berretta. Neuropsychopharmacology, 2001

1,089 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f488517c7bf55052475e4c5b4ea4ac5c42a59d6d

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Citations in the corpus

Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis (2006, methodology): “…and DNA chip array methods, have confirmed the reduction in the presynaptic markers for GABAergic inter-neurons in subsectors of the hippocampal formation and in the intermediate layers of the prefrontal and cingulate cortex [for reviews, (Benes and Berretta, 2001; Lewis et al., 2004)].”
The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, neutral): “However, several reports have shown decreases in these proteins in schizophrenia.(97,98,100) Hashimoto et al(94) showed a downregulation of parvalbumin gene, and Vawter et al(93) showed downregulation of glutamate receptor a-amino-3hydroxyl-5-methyl-4-isoxazoleproprionate (AMPA).”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “In rodent PFC, both D1- and D2-like receptors are found on pyramidal and non-pyramidal neurons (Vincent et al., 1993; Benes and Berretta, 2001).”
Molecular Structure and Physiological Functions of GABAB Receptors (2004, background): “On the contrary, hyperactivity of the GABAergic system was associated with schizophrenia (20).”
Clinical course of children and adolescents with bipolar spectrum disorders. (2006, neutral): “(%) 180/263 (68) 104/152 (68) 15/19 (79) 61/92 (66) NS Median time to recovery from the index episode,‡ wk 78.”
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. (2008, background): “Hypofunctioning GABAergic interneurons appear to be important in the etiology of major psychosis.(27) Our data suggest that MARLIN-1, a RNA-binding protein that is widely expressed in the brain and regulates the production of functional GABA(B) receptors,(36) is hypermethylated in SZ, BD, and major-”