Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
By A. Guidotti, J. Auta, J. Davis, V. Di-Giorgi-Gerevini, Yogesh Kumar Dwivedi, D. Grayson, F. Impagnatiello, G. Pandey, C. Pesold, R. Sharma and 2 more. Archives of General Psychiatry, 2000
1,208 citations recorded by the source corpus.
Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Developmental Neuroscience
View Paper: https://www.semanticscholar.org/paper/e6521eba8e83a2e34edc8298d474c4ab1bd3b2ec
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In Behavioral Neuroscience
In Cellular and Molecular Neuroscience
Citations in the corpus
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. (2008, result): “These observations were confirmed and extended in subsequent studies showing alteration in several presynaptic components of the GABAergic system [8–14].”
- GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder (2001, background): “More recently, a decrease in GAD67 mRNA, but not GAD65, expression has again been noted (Guidotti et al. 2000).”
- Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia (2003, background): “…the mRNA and protein for the 67 kDa isoform of glutamate decarboxylase (GAD 67 ), a synthesizing enzyme for GABA, in the PFC (Akbarian et al., 1995; Guidotti et al., 2000; Volk et al., 2000) are among the most robust and diagnostically specific findings in postmortem studies of schizophrenia…”
- The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, positive): “Reduction in reelin was associated with significant decreases in GAD67-kDa protein in the same postmortem brains.(178) A later immunocytochemical report(179) showed significant reductions in reelin immunoreactivity in schizo-”
- The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “…research groups have found decreased expression of the mRNA for the 67 kilodalton isoform of glutamic acid decarboxylase (GAD 67 ), the synthesizing enzyme for GABA, in the dorsal prefrontal cortex (Akbarian et al. 1995; Guidotti et al. 2000; Volk et al. 2000) of subjects with schizophrenia.”
- Animal models of schizophrenia (2011, background): “Furthermore, both reelin mRNA and GAD67 mRNA expression have been found to be significantly decreased in GABAergic interneurones in the superficial layers of the PFc in patients with schizophrenia (Guidotti et al., 2000).”