T-cell development and the CD4–CD8 lineage decision

By Ronald N. Germain. Nature reviews. Immunology, 2002

887 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/63daa4caae4b7f0839b3a773259609358710c215

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Citations in the corpus

Control of regulatory T cell lineage commitment and maintenance (2009, background): “T cell receptor (TCR) signals of distinct strength and duration have been proposed to guide CD4 versus CD8 T cell fate decision during thymic differentiation (Germain, 2002; Singer et al., 2008).”
Human T cell development, localization, and function throughout life (2018, background): “Most of our knowledge of thymopoiesis, the genesis of new T cells and mechanisms for their selection and development derive from studies in mouse models using thymectomy, bone marrow reconstitution, and genetic manipulation (for reviews, see (Germain, 2002; Klein et al., Immunity.”
Quantitative challenges in understanding ligand discrimination by αβ T cells (2008, background): “The simplest view of this ‘erasure’ of overt responsiveness o positively selecting ligands that do not also induce subseuent negative selection (Guidos et al., 1990; Germain, 2002) s that the maturing T cells increase the threshold necessary for ctivation in a global sense.”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “During thymic differentiation, variations in TCR signaling characteristics such as functional avidity and duration are central determinants of T cell lineage fate determination, informing the CD4 or CD8 T cell choice (38, 39) and the differentiation of specialized T cell subsets, which include NKT c”
Deletion of β-catenin impairs T cell development (2003, background): “Essential positive selection signals from the TCR result in the generation of CD4 + T helper cells bearing major histocompatibility complex (MHC) class II–restricted TCRs and CD8 + cytolytic T cells bearing MHC class I–restricted TCR”
Control of lymphocyte development by nuclear factor-κB (2005, neutral): “T-cell development in the thymus starts with CD4 − CD8 − double negative (DN) thymocytes, which progress to CD4 + CD8 + double positive (DP) thymocytes and finally to CD4 + or CD8 + single positive (SP) thymocytes, which exit the thymus and enter the circulatio”
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells (2004, background): “Those thymocytes whose TCRs bind to MHC molecule–self peptide complexes with moderate affinities are positively selected for further maturation, and quantitative differences in the strength of the positively selecting signal may condition the choice of lineage toward the CD4 + or CD8 + compartmen”