Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation.

By C. Keck, R. Müller. European journal of pharmaceutics and biopharmaceutics, 2006

1,083 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/63bbd215370c9ce93d1e1a83f21959442db859c5

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Citations in the corpus

Drug Solubility: Importance and Enhancement Techniques (2012, methodology): “The concern with this method is the need for small sample particles before loading and the fact that many cycles of homogenization are required [32].”
Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds (2008, background): “Alternatively, nanoparticles can be successfully generated using drug-fragmentation processes such as homogenization (Liedtke et al., 2000; Keck and Muller, 2006), microfluidation (Pace et al.”
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, background): “Thus comminution of particles is achieved by collision of particles with each other, collision with the homogenizer and by cavitation and the two factors that inﬂuence homogenization in this process are the pressure drop and the number of passes across the homogenizer [17,31,32].”
High drug-loading nanomedicines: progress, current status, and prospects (2017, neutral): “182 The first DNC product for oral application (named Rapamune ® ) was successfully introduced to the market by Wyeth in 2000.”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “…overcome the challenges to absorption presented by compounds with very low aqueous solubility (,1 mg/ml) (Kondo et al., 1993; Muller et al., 2001; Keck and Muller, 2006; Gao et al., 2008), and alternative methods have been developed to reduce particle size further and to isolate particles with…”
Nanosuspension: An approach to enhance solubility of drugs (2011, background): “[17] Other homogenization technologies and patents on the homogenization processes are shown in Table 2.[18]”
Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. (2008, background): “…Gupta, 2006), their manufacturing techniques (Jahnke, 1998; Horn and Rieger, 2001; Müller et al., 2003; Date and Patravale, 2004; Hu et al., 2004; Keck and Müller, 2006; Müller et al., 2006) and oral or parenteral applications of nanosuspensions (Kipp, 2004; Rabinow et al., 2006; Kesisoglou et…”