Fibroblast biology in three-dimensional collagen matrices.

By F. Grinnell. Trends in Cell Biology, 2003

852 citations recorded by the source corpus.

Subfields: Biomaterials, Cell Biology, Genetics

View Paper: https://www.semanticscholar.org/paper/63b7a00f5c64c8421de9af26d90a2b079f01983d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. B. Hinz
2. Christopher S. Chen
3. Brendon M. Baker

In Cell Biology

1. B. Hinz
2. Brendon M. Baker
3. Christopher S. Chen
4. G. Krupitza
5. P. Keely
6. Nikolaos G. Frangogiannis

In Genetics

1. B. Hinz
2. Christopher S. Chen
3. C. López‐Otín
4. Brendon M. Baker

Citations in the corpus

• Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP (2004, background): “Like tumor cells, fibroblasts are also endowed with the ability to remodel and infiltrate collagen-rich tissues as a function of their roles in growth, development, wound healing, and inflammation (Grinnell, 2003; Dong et al., 2004).”
• Focal adhesion regulation of cell behavior. (2004, background): “The specifics of these studies are well explained in a recent review [177].”
• Modeling Physiological Events in 2D vs. 3D Cell Culture. (2017, background): “Cell migration differs between dimensionalities (11, 42, 45), potentially due to the more complex cell interactions within a 3D substrate.”
• Modeling tissue morphogenesis and cancer in 3D. (2007, neutral): “For example, collagen gels can mimic loose or dense connective tissue depending on the concentration of collagen; such gels have been used widely in studies of fibroblast and tumor cell migration and signaling (Grinnell, 2003).”
• The Basic Science of Wound Healing (2006, background): “The molecule undergoes the following eight posttranslational steps until it is secreted as procollagen116: (1) cleavage of the signal peptides; (2) hydroxylation of the proline or lysine amino acids in the x-position to 4-hydroxyproline or 4-hydroxylysine; (3) hydroxylation of some proline residues ”
• Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “These materials include purified collagen type I (A in Figure) (Grinnell, 2003), fibrin gels formed by thrombin cleavage of fibrinogen, reconstituted basement membrane (e.g. Matrigel) (Kleinman and Martin, 2005) and stromal ECM synthesized by fibroblasts (C in Figure) (Beacham et al., 2007).”
• Perspective Article: Tissue repair, contraction, and the myofibroblast (2005, background): “Changes in the physical stress caused by stretch of granulation tissue may also contribute to the loss of cells via an apoptotic mechanism as has been suggested by in vitro studies of fibroblasts in collagen lattices.(17) Furthermore, a cross talk between epidermis and dermis exists through the base”
• Formation and function of the myofibroblast during tissue repair. (2007, result): “The stiffness of the provisional ECM of early wounds is comparable with the elastic modulus of B10–100 Pa of newly polymerized collagen gels (Kaufman et al., 2005), frequently used in vitro models of tissue repair (Grinnell, 2003; Carlson and Longaker, 2004).”
• In vitro cell migration and invasion assays. (2013, background): “extracellular matrix, cytoskeletal contractility and elongated spindle-like cell bodies [21].”