Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

By T. Aoi, K. Yae, M. Nakagawa, T. Ichisaka, K. Okita, Kazutoshi Takahashi, T. Chiba, S. Yamanaka. Science, 2008

1,067 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/63b16056a71c57acfb530085c7ec8025c0567aaa

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In Molecular Biology

Citations in the corpus

Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “It is apparent that the exogenous transcription factor requirements for inducing pluripotency vary with the starting cell type as do the efficiency and kinetics of molecular reprogramming (Aoi et al., 2008; Kim et al., 2008; Silva et al., 2008).”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “Although it has been demonstrated that the viral integration is not directly linked to the reprogramming proces”
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition (2008, background): “Fully reprogrammed iPS cells have previously been generated from fibroblasts [1,29] and other cell types [3,5,28] without a defined pre-iPS intermediate.”
Epigenetic memory in induced pluripotent stem cells (2010, background): “Keratinocytes reprogram more readily than fibroblasts 9 , and iPSC from stomach or liver cells harbor fewer integrated proviruses than fibroblasts, suggesting they require lower levels of the reprogramming factors to achieve pluripotency 10 .”
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. (2008, background): “It was later shown that iPSCs can be generated by viral integration of Oct4/Sox2/ Klf4 without c-Myc (Aoi et al., 2008; Nakagawa et al., 2008).”
Oct4-induced pluripotency in adult neural stem cells. (2009, neutral): “Analysis of previously described iPS cells revealed up to 20 retroviral integrations for all four factors (Aoi et al., 2008; Wernig et al., 2007).”
Induced pluripotent stem cells: past, present, and future. (2012, positive): “Mice derived from retrovirally derived iPSCs are apparently normal, as long as expression of the c-Myc transgene is repressed (Aoi et al., 2008; Nakagawa et al., 2008).”