Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

By Angela Montecalvo, A. Larregina, W. Shufesky, D. Stolz, Mara L. G. Sullivan, J. Karlsson, C. Baty, G. Gibson, G. Erdos, Zhiliang Wang and 7 more. Blood, 2012

1,377 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/637bd9de7918434632f1830313cdbc929c678d2a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, neutral): “1c) [29, 31].”
Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “miRNA transfer from DC to DC has been shown to involve EVs and to lead to alterations in recipient cell gene expression [77].”
Exosomes and other extracellular vesicles in host–pathogen interactions (2014, neutral): “Exosomes released by immune cells have been shown to contain a selective repertoire of miRNAs that can be functionally transferred to recipient cells [58,59].”
Quantitative and stoichiometric analysis of the microRNA content of exosomes (2014, background): “Although this very small size implies that exosomes have a very limited capacity to sample the diverse RNA repertoire, some studies have reported that certain miRNA sequences are enriched in exosomes relative to their cells of origin (4, 10).”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Thus, intercellular exchange of miRNAs by vesicles can affect post-transcriptional regulation (Montecalvo et al., 2012).”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, methodology): “Similarly, extensive comparison of intracellular and extracellular miRNA has now shown a selection of specific sequences of miRNA for extracellular export as well (Montecalvo et al. 2012).”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “Consistent with this observation, mouse plasmacytoid DCs (which express Siglec-H) were able to capture EVs in vivo (447).”
Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions (2012, background): “Evidence exists that miRNAs associated to cell-derived vesicles are functional upon transfer to target cells (17,18).”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “Exosomes and MicroRNA Biogenesis preparations were treated with proteinase K before exosomal protein extraction, as previously described (Montecalvo et al., 2012) (Figures 3A, 3B, and S3A).”