Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila

By Kwang-Min Choe, Thomas Werner, Svenja Stöven, D. Hultmark, K. Anderson. Science, 2002

620 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Immunology, Insect Science

View Paper: https://www.semanticscholar.org/paper/6341dcb761804f61dbaa4a92c7024f14114d3806

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology, Evolution, Behavior and Systematics

1. Y. Moret
2. M. Siva‐Jothy
3. M. J. Lehane
4. Gerald M. Rubin
5. M. Strand
6. J. Rolff
7. P. Schmid-Hempel
8. Jeffrey A. Harvey

In Immunology

1. J. Hoffmann
2. M. J. Lehane
3. B. Lemaître
4. M. Strand
5. Y. Moret
6. J. Rolff
7. M. Siva‐Jothy
8. Jing-Huan Wang

In Insect Science

1. J. Hoffmann
2. M. J. Lehane
3. B. Lemaître
4. M. Strand
5. J. Rolff
6. Y. Moret
7. M. Siva‐Jothy
8. Jing-Huan Wang

Citations in the corpus

• Role of Toll-Like Receptors in Pathogen Recognition (2003, background): “by on February 21, 2010 cmr.asm.org Downloaded from PGRP-LC is a transmembrane receptor, identified by three different groups as the long-sought gram-negative receptor upstream of the immune deficiency pathway (Fig. 3B) ( 10 , 17, 63).”
• The Drosophila immune system detects bacteria through specific peptidoglycan recognition (2003, background): “PGRP-LC, a putative transmembrane protein, acts upstream of the Imd pathwa”
• Invertebrate immune systems – not homogeneous, not simple, not well understood (2004, background): “De Gregorio E, Spellman PT, Rubin GM, Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays.”
• The Toll and Imd pathways are the major regulators of the immune response in Drosophila (2002, background): “Recently, three independent studies have shown that a putative transmembrane protein, PGRP-LC acts upstream of Imd and probably functions in sensing microbial infection (Choe et al., 2002; Gottar et al., 2002; RaÈmet et al., 2002b).”
• The biology of blood-sucking in insects (2005, positive): “It is already known that the family of peptidoglycan recognition proteins (PGRPs) are insect PRR (Choe et al., 2002; Gottar et al., 2002; Kurata, 2004; Michel et al., 2001; Ramet et al., 2002b).”
• Insect Immunity: An Evolutionary Ecology Perspective (2005, background): “Mutants of PGRP–LC fail to respond to G , but not G bacteria (Choe et al., 2002; Rämet et al., 2002b).”
• The immune response of Drosophila (2003, background): “Activation of the Imd pathway requires a putative transmembrane protein that is also a member of the PGRP family (PGRP-LC”
• The Drosophila Toll Signaling Pathway (2011, background): “In turn, Imd signaling is initiated by the PGRP-LC–mediated recognition of mainly a DAP-type PGN from Gram-negative bacteria (74, 81).”