EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS

By G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, A. Lunts, W. Kreyling, C. Cox. Journal of Toxicology and Environmental Health, Part A, 2002

1,085 citations recorded by the source corpus.

Subfields: Environmental Engineering, Health, Toxicology and Mutagenesis, Pollution

View Paper: https://www.semanticscholar.org/paper/633a6fa2418c65e7ef1f853401d2294684b1c71f

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Citations in the corpus

Deposition and biokinetics of inhaled nanoparticles (2010, background): “Either, nanoparticles were found in the blood circulation [31,90] and in secondary target organs [11-13,91-94], or thrombogenic effects were observed [95-97].”
In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. (2005, background): “Systemic distribution of nanoparticles has been demonstrated after inhalation and oral uptake (Jani et al., 1990; Oberdorster et al., 2002), and nanoparticles have been found to cross the blood–brain barrier, reaching the olfactory bulb and the cerebellum (Borm and Kreyling, 2004; Oberdorster et…”
Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells (2005, background): “1990) and are subjected to clearance by cough, mucociliary transport, and/or phagocytosis by macrophages, UFPs seem to penetrate the boundary membranes of the lungs rapidly—a unique feature for insoluble particles (Brown et al. 2002; Kreyling et al. 2002; Oberdörster et al. 2002).”
Translocation of Inhaled Ultrafine Particles to the Brain (2004, background): “Supportive of a circulatory route of UFP translocation from deposits in the respiratory tract are results of our previous study (Oberdörster et al., 2002).”
Nanotoxicology and in vitro studies: the need of the hour. (2012, background): “…distribution of particles to the lungs, liver, heart, kidney, spleen and brain (BeruBe et al., 2007; Hagens et al., 2007; Medina et al., 2007; Oberdorster et al., 2002) and clearance via phagocytosis in the alveolar region by macrophages (Curtis et al., 2006; Garnett and Kallinteri, 2006;…”
TRANSLOCATION OF ULTRAFINE INSOLUBLE IRIDIUM PARTICLES FROM LUNG EPITHELIUM TO EXTRAPULMONARY ORGANS IS SIZE DEPENDENT BUT VERY LOW (2002, background): “In contrast to these findings using ultrafine iridium particles, studies by Oberdörster et al. (2002) using ultrafine 25-nm 13C carbonaceous particles suggest a major translocation pathway from the respiratory tract to the liver within the first 24 h.”
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. (2005, background): “Such penetration raises the possibility of further translocation into systemic circulation as has been earlier documented for other ultrafine particles (10, 19).”
Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults (2008, background): “…the clearance of foreign material arriving from the circulation and the gut (Wake et al. 1989)—is a very interesting finding, given that the liver and the digestive tract are preferred sites for extrapulmonary translocation of ultrafine particles in human beings and rats (Oberdorster et al. 2002).”