Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.

By A. Shvedova, E. Kisin, R. Mercer, A. Murray, V. Johnson, A. Potapovich, Y. Tyurina, O. Gorelik, S. Arepalli, D. Schwegler-Berry and 9 more. American Journal of Physiology - Lung cellular and Molecular Physiology, 2005

1,308 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry, Plant Science

View Paper: https://www.semanticscholar.org/paper/a8ba9c1c228aa823fbe27dd7d43ddb1ea27e02bf

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Citations in the corpus

Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. (2006, methodology): “As described earlier, CNT tend to aggregate into ropes, and these may be visible but they may not be greater than 5 lm in length, especially if, as has been observed for some CNT, they are not rigid and so they curl up (Maynard et al., 2004; Shvedova et al., 2005).”
Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy (2005, background): “Multiwalled carbon nanotubes (MWCNT) are persistent in the deep lung after inhalation and, once there, are able to induce both inflammatory and fibrotic reactions [47].”
A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. (2008, neutral): “Following intratracheal instillation of SWNTs, a dose-dependent inflammation and formation of small nodules, known as epitheloid granuloma, has been seen in the lungs of animal”
Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “These results may explain why the rapid and progressive interstitial fibrotic response to SWCNTs can proceed in the absence of robust macrophage activation or the presence of prior pulmonary inflammatio”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, methodology): “Fibre rigidity is dependant on the synthesis method, but even the rigid nanomaterials rarely exist as individual units and are attracted to one another by van der Waals forces with a tendency to curve and twist forming bundles [174,175].”
Occupational exposure limits for nanomaterials: state of the art (2010, background): “For example, evidence for carbon nanotubes (CNTs) (which are rolled sheets of graphene) and for ultrafine titanium dioxide illustrates that current OELs for bulk materials are not adequate for nanoscale variants of the same composition ( Shvedova et al. 2005; Kuempel et al. 2006; Dankovic et al. 20”
Biomedical applications of functionalised carbon nanotubes. (2005, background): “One study even suggested that in addition to these primary effects, CNTs may also have an impact on the resistance to pathogens as co-inhalation of pathogenic bacteria and SWNTs slows down the clearance of bacteria from the lungs (Shvedova et al., 2005).”