HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

By S. Khakoo, C. Thio, Maureen P. Martin, Collin R. Brooks, Xiaojiang Gao, J. Astemborski, Jie Cheng, J. Goedert, D. Vlahov, M. Hilgartner and 8 more. Science, 2004

1,229 citations recorded by the source corpus.

Subfields: Hepatology, Immunology

View Paper: https://www.semanticscholar.org/paper/62f490814d07adaedd69aa18a1ad3b756cc71bcd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. B. Rehermann
2. M. Nascimbeni

In Immunology

1. Peter Parham
2. A. Moffett
3. Christopher W. G. Redman
4. B. Rehermann
5. M. Nascimbeni

Citations in the corpus

• Adaptive immune responses in acute and chronic hepatitis C virus infection (2005, background): “For instance, although natural killer (NK) cells are an important direct mediator of the innate immune response that have been implicated in the control of HCV infectio”
• Immunology of hepatitis B virus and hepatitis C virus infection (2005, background): “A role for NK cells in early HCV infection was recently indicated by a large immunogenetic study in which the presence of a specific NK-cell receptor–HLA COMPOUND GENOTYPE correlated with HCV clearance and clinical recover”
• Redefining chronic viral infection. (2009, neutral): “For example, interactions between killer inhibitory (KIR) alleles encoding NK cell receptors and MHC class I alleles contribute to susceptibility to HIV, HCV, and EBV infection (Khakoo et al., 2004).”
• Natural killer cells act as rheostats modulating anti-viral T cells (2011, neutral): “Recent genetic evidence, however, has indicated a correlation between certain natural killer (NK)-cell receptors and progression of both HIV and HCV infectio”
• Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success (2004, background): “Clinically, HLA-C1 and C2 have been shown to have diverse effects in both HLA-identical stem cell transplantation, and Hepatitis C infection (40, 41).”
• IPD—the Immuno Polymorphism Database (2012, neutral): “All expressed HLA-C alleles are of the C1 or C2 group (8) and most HLA-B alleles can be classified as either Bw4 or Bw6 (9).”
• MHC class I molecules and kirs in human history, health and survival (2005, background): “For people who are infected by injection or by injury with an HCV-contaminated needle, homozygosity for both KIR2DL3 and group C1 allotypes is associated with increased resolution of infectio”