Transcription of eukaryotic protein-coding genes.

By Tong Ihn Lee, Richard A. Young. Annual Review of Genetics, 2000

957 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6293e2583fb6d45bd9b651996843525de6cea626

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In Molecular Biology

Citations in the corpus

DEEP: a general computational framework for predicting enhancers (2014, background): “The better-characterized distal regulatory elements in eukaryotes are enhancers, silencers and insulators (4,5).”
Transcriptional regulatory elements in the human genome. (2006, neutral): “Enhancers were first identified as regions of the SV40 tumor virus genome that could markedly increase the transcription of a heterologous human gene containing a promoter (7, 13, 103).”
The evolution of transcriptional regulation in eukaryotes. (2003, background): “For more detailed reviews of mechanisms of eukaryotic transcriptional regulation see Latchman (1998), Weinzierl (1999); Carey and Smale (2000), Lee and Young (2000), Lewin (2000), Davidson (2001), Locker (2001), and White (2001).”
The General Transcription Machinery and General Cofactors (2006, background): “The CTD contains a tandem repeat of a heptapeptide: Tyr-SerPro-Thr-Ser-Pro-Ser (YSPTSPS), which repeats 52 times in humans, 42 times in Drosophila, and 26 to 29 times in yeast, depending upon the species (Dahmus, 1995; Hampsey, 1998; Lee and Young, 2000).”
The RNA polymerase II core promoter: a key component in the regulation of gene expression. (2002, background): “By complex formulae that have yet to be solved, the expression of each of these thousands of genes is controlled by a wide variety of mechanisms (e.g., see Lefstin and Yamamoto 1998; Roeder 1998; Struhl 1999; Glass and Rosenfeld 2000; Lee and Young 2000; Lemon and Tjian 2000; Strahl and Allis 2000; ”
Network Motif Discovery Using Subgraph Enumeration and Symmetry-Breaking (2007, background): “This includes a complete 11-node graph (including the two central hubs) corresponding to the SAGA complex, and consisting almost entirely of chromatin modification and histone acetylation factors an 8-node core (shared by all instances of the 15-node motif) corresponding to the TFIID complex, and 12”
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation (2010, neutral): “Thus, numerous studies in yeast and metazoan systems that aimed to identify the co-factors which enable the functions of diverse transcriptional activators identified Mediator as a Pol II- and activator-interacting multiprotein comple”
Structure and mechanism of the RNA polymerase II transcription machinery (2004, background): “The general factors are involved in recognition of promoter sequences, the response to regulatory factors and conformational changes essential to the activity of Pol during the transcription cycl”
Plant Transcription Factors (2011, background): “sativa; rice), enabled a comprehensive identification of genes encoding for TFs (some little conserved putative TFs that have not been identified notwithstanding) (1, 2).”